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Acknowledgements This work was supported by a grant from the Department of Health in Taiwan (grant number: DOH94-TD-F-113044) for cohort establishment, and by grants (grant numbers: TCMMPSP104-08-02, TCMMP105-13-05, TCMMP106-04-01) from the Buddhist Tzu Chi Medical Foundation for cohort follow-ups and linkage to the National Health Insurance Research Database