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(2) Druggability and chronic dosing toxicity risks: Most UPS-targeted candidates suffer from common druggability issues such as low solubility, poor membrane permeability and insufficient metabolic stability (Wu et al

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In the spring of 2012, inspired by the Trinity Session, Cocteau Twins, Red House Painters, Mazzy Star & the sound of early '60s records like "I Love You How You Love Me" by the Paris Sisters, they recorded their first proper EP, I., live over the course of a single night in the stairway of a four story building.