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Alamgir and his colleagues also stratified patients by smoking history, including whether or not individuals were former smokers or never smokers, and the cohorts were matched 1:1 using propensity scores based on age, sex, race, ethnicity, metastatic status, and comorbidities. Furthermore, the study team defined the primary outcomes as OS and TTNT, with TTNT being defined as time from osimertinib initiation to receipt of any subsequent antineoplastic therapy, with follow-up starting 14 days after osimertinib initiation to avoid miscalculation. Investigators also noted that a sensitivity analysis excluding smoking-related comorbidities was performed to assess the impact of overadjustment. After matching, 1,612 patients were included in each of the study cohorts
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