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INH is mainly metabolized in the liver through two major pathways to metabolites such as acetyl isoniazid (AcINH), hydrazine (Hz), acetyl hydrazine (AcHz), diacetyl hydrazine (DiAcHz), and isonicotinic acid (INA), primarily mediated by arylamine N-acetyl transferase2 (NAT2) and amidases (Wang et al., 2016

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[107] The nanoparticles can be produced by the heating element or by pyrolysis of chemicals directly touching the wire surface