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A recent study has demonstrated that nicotine exerts deleterious effects on renal function by modulating the 7nAChR, NLRP6 inflammasome, endoplasmic reticulum (ER) stress, and autophagy pathways ( Slow nicotine metabolizers exhibit lower levels of inflammation (ICAM-1 and PGEM) compared to fast metabolizers, which is linked to kidney damage (44)

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The researchers found that the solvents created 31 harmful chemicals, including propylene oxide and glycidol, both of which are probable carcinogens

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