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2000 titled Initial symptoms of nicotine dependence in adolescents. However, this time frame varies significantly based on several factors, including the frequency of use, the method of consumption (such as smoking or using smokeless tobacco), and genetic predisposition
2427 Five studies investigated the association of baseline anxiety on smoking onset, of which four (80%) found evidence to support an association with increased risk of smoking onset 24,2830 and one (20%) found no evidence of an association
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We sought to overcome these limitations by integrating across brain regions, behaviors, and model organisms, but future studies are needed to determine whether these effects are invariant and to determine what paradigms are most relevant to what human traitsespecially as the volume of literature increases
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