Tobacco product use remains the leading cause of preventable disease and death in the U.S., accounting for more than 480,000 deaths annually, according to the Centers for Disease Control and Prevention
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in oral cancer is multifaceted due to its inherent properties, such as its potential to form biofilms, ability to co-aggregate with other microbes, immunomodulatory potential, virulence factors, and secretion of some metabolites involved in both pro- and anti-carcinogenic mechanisms
flavor capsule cigarettes) by creating associations that persist across cultures
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