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For our SNP-HSI association testing, we followed the model employed by systemic GWAS analyses for a multitude of phenotypes (see adjusting for the following covariates: sex, age, age 2 , age sex, age 2 sex, and PC eigenvectors, with the age 2 and interaction terms among the age and sex variables intended to account for non-linear associations
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Delnevo CD, Gundersen DA, Manderski MTB, Giovenco DP, Giovino GA
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