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Metals like cadmium and lead, along with radioactive elements such as polonium-210, further contribute to cancer risk by creating oxidative stress and additional DNA damage

The cigarette makers say their products have had medical warnings for more than 45 years, but that they never filed a legal challenge against them until these images were approved

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These variables were selected a priori as plausible confounders because of their established associations with both smoking and e-cigarette use behaviour and cardiovascular health