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Smokers also tend to have lower wages, higher health care costs and higher home insurance premiums. Chip Lupo, WalletHub Analyst Costs Over a Lifetime Note: *No.1 = Costliest Costs per Year Note: *No.1 = Costliest In-Depth Look at the Costliest States for Smoking District of Columbia The place with the highest lifetime cost of smoking is the District of Columbia, at a little under $5.9 million