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Second, while we had 10 suitable case-control studies, only 2 cohort studies were found to be suitable with sufficient data for an up-to-date metaanalysis

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Furthermore, as this study shows, with cigarettes being taxed at both the state and federal levels in the USA, the combined federal and cigarette tax incidence on cigarettes remains to be higher than the incidence on closed-system ENDS, leaving an economic incentive for smokers to switch to ENDS