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Nicotine has been shown to be a substrate and/or inhibitor of SLC transporters subtype organic cation transporters (OCTs) such as OCT1 -3, organic cation/carnitine transporters (OCTn), multidrug and toxin extrusion protein 1 (MATE 1), and plasma monoamine transporters (PMAT) in various cell lines that were transfected with these transporters (Urakami et al., 1998

Hung LY, Lyons JG, Wu CH