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Watch: Why burning is the main problem with smoking Learn how removing the burning from tobacco makes better alternatives to smoking

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Roles of UPS in the P53 signaling pathway P53, a 53 kDa tumor suppressor protein, orchestrates metabolic reprogramming and reactive oxygen species (ROS) homeostasis under various stress conditions, including DNA damage and oncogenic signaling (Oren and Prives 2024)

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Therefore, smoking status does not have to be considered as it does for those with the highly inducible variant