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Cohort (i.e., generational) effects reflect the impact of macro-level contextual (e.g., environmental, social, cultural) pressures across the life course on a group of individuals born within a specified period (i.e., birth cohort) 5

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The ability of the VLNC intervention to promote smoking cessation was specifically tested at week 12 when participants were offered $100 to abstain from smoking for 24 hours, a modest goal given that most smokers who abstain for 24 hours relapse, and smokers do not get such offers in real life

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The legislation requires manufacturers to submit product applications for FDA review and required all synthetic nicotine products off the market by July 12, 2022

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