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+ Higher nicotine concentrations require fewer puffs for satisfaction: 3-6mg freebase: 30-50 puffs per cigarette equivalent 10-12mg nic salt: 15-25 puffs per cigarette 18-20mg nic salt: 10-15 puffs per cigarette Heavy smokers benefit from 18-20mg to satisfy cravings with reasonable puff counts

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Exposure to second-hand cigarette smoke exacerbates the progression of osteoarthritis in a surgical induced murine model