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his Master of Science degree from Amirkabir University of Technology in Tehran, Iran

This is due to repeated and rapid contractions increasing metabolic demand in the muscles, swiftly depleting energy stores, and accumulating lactate, a metabolic byproduct contributing to the sensation of fatigue 17

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When you smoke up to 20 [a day] it gives you more risk, but not hugely more. Men smoking one cigarette a day had 53% of the coronary heart disease risk of those smoking 20 a day, and 64% of their risk for stroke