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On average, a heavy smoker can have cotinine levels ranging from 1,000 to 5,000 nanograms per milliliter (ng/mL) of urine

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The ambiguity may be attributed to the 2009 Tobacco Control Acts (TCA) restrictions on making harm reduction claims (i.e

Using a can per day could cost almost $1,100 a year

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Nicotine accumulates in the body and a tolerance develops, leading to increased usage