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Over the coming years, experts said, FDA regulators will wrestle with a basic question about e-cigarettes and the fast-growing range of other vaping devices: Even if they pose some dangers to consumers, are they safer than cigarettes

While the association was strongest for traditional smokers, the study noted that vaping alone may still carry cardiovascular risks, although the smaller number of exclusive vapers in the sample limited statistical certainty

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Additionally, two sensitivity analyses were conducted: one assessing the impact of including only studies with objective COPD diagnoses (e.g., spirometry) while excluding self-reported cases, and another including only studies with a NOS score 7 to evaluate the effect of study quality on the results