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Taken together, in conjunction with the aforementioned increased expression of exosomal miR-21 in patients with OLK, we propose that exposure of CSE increases the secretion of miR-21 + exosomes, which promotes the polarization and expression of Arg-1 and IL-10 of M2 macrophages

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CSE treatment elevated IL1B expression in a dose-dependent manner, decreased IL23A expression at the highest dose, and had no effect on IL33 expression (Fig