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A crossover study of smokers showed that the use of IQOS, e-cigarettes, or CS was associated with acute oxidative stress, platelet function, flow-mediated dilation, and blood pressure, with CS being the most detrimental among the three products 105

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The second step in the approach was to estimate the number of non-alcohol-attributable deaths in Canada (i.e., the deaths that would occur if no one person consumed alcohol)

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