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The loss of smell has been one of the key mysteries and these findings offer an answer, along with previous findings of changes to the olfactory bulb in the nervous system. In Covid-19 patients, persistent olfactory problems have been shown to be associated with the shrinking of brain regions related to our sense of smell, said Dr Gwenalle Douaud, a neuroscientist who has studied the effects of Covid on the brain at the University of Oxford