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Sample Size and Power Calculations As no data are available in the literature on the efficacy of varenicline for gradual cessation in patients with COPD who are poorly motivated to quit, our sample size calculation was based on the cessation rates observed for abrupt cessation in patients with COPD motivated to quit smoking receiving a combination of varenicline and smoking cessation counseling

In light of new bans on smoking advertising smokeless tobacco is being advertised as an alternative to cigarettes

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