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77 , 78 MAXIMIZING PHARMACOLOGIC EFFECTIVENESS To enhance the safety and efficacy of all the pharmacologic agents for nicotine withdrawal, provide written instructions for proper use, individualize dose and duration of therapy, schedule frequent office visits or phone calls to monitor patient response, and adjust dose and duration of treatment accordingly

Poredos P, Orehek M, Tratnik E

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Even medical users can develop tolerance or dependency over time

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