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For instance, acrolein has been found to inhibit CYP450 enzymes (173), and formaldehyde specifically reduces the levels of CYP2C11, CYP2E1, and CYP3A2, but increases CYP1A2, in male rats (166)

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However, due to the paucity of experimental data and contradictory evidence, it is difficult to draw conclusive outcomes regarding toxicological, immunological and clinical impacts of e-cig aerosols

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In doing so it is important to keep in mind that smoking trends lead mortality trends by 20 to 30 years (Lopez et al., 1994)

"UCSF Tobacco Industry Audio Recordings"