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Tobacco smoking is also the leading cause of chronic obstructive pulmonary disease (COPD), a condition where lung tissue is damaged over time and mucus builds-up in the airways

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Relative risks for dual users may be less than for exclusive smokers due to reduced quantity smoked [43], but studies have found similar risks [52, 53] except with large quantity reductions [54]

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As well as the presented calculations included only patients with CH without any co-existing headache or severe systemic disease, therefore it may be the cause of non-significant association between CH and smoking