Chewing tobacco, while not yet causally related, increases the risk for cancer of the esophagus, colon, bladder, and voice box
Following several fatalities from the consumption of pure caffeine powder in 2014, the FDA issued warnings about concentrated caffeine products and banned bulk sales of powders and liquids containing pure or concentrated caffeine
"City of Fargo 2022 Annual Comprehensive Financial Report" (PDF)
Read about symptoms, stages, treatment, and home remedies
For both the pipe and cigarette smoker, this means that the smoke will be sharper and slightly irritating in the mouth
Many thanks to Jeremy McKenna at Sutliff and Oliver Kopp for helping out.