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Taken together, these unique gene changes are strongly suggestive of an increased inflammatory burden after LC exposure that may be associated with greater airways remodeling

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There are many likely causes for this decline, including public health messaging, the growth of substitute products, and changes in federal, state, and local policies

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It has to be said that their simplicity has won over smokers with the least technological ease, or former vapers who were disappointed by a first purchase of a classic e-cigarette (too complicated, too much maintenance, too many problems) because they were poorly advised, or smokers simply wanting to try e-cigarettes at a lower cost and without commitment