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There is also growing evidence that chronic ER stress through regulation of several pathways leading to oxidative stress, inflammation, perturbed hepatic lipid homeostasis, apoptosis, and autophagy, can also induce hepatic steatosis and its progression to NASH

4.3 Acid pretreatment Acidic reagents have demonstrated the ability to break glycosidic bonds in lignocellulose, effectively dissolving cellulose, hemicellulose, and small amounts of lignin, thereby promoting the release of fermentable sugars ( The acid pretreatment of tobacco stems generally employs dilute acids, primarily to remove hemicellulose and enhance the accessibility of cellulose to enzymes