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Pregnant or breastfeeding women should also avoid nicotine gum due to potential risks to the baby, with evidence that nicotine can impact the developing brain

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Nicotine and/or cigarette smoke have been reported to impair RAAS homeostasis in multiple organ systems by upregulating the ACE/ANG-II/AT1R axis and downregulating the compensatory ACE2/ANG-(1-7)/Mas receptor axis (Oakes et al., 2018)

Alcohol also causes fatty liver disease, cirrhosis of the liver, and alcohol hepatitis

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