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Synthetic Nicotine: Also known as tobacco-free nicotine(TFN), this type of nicotine is similar to nicotine salts but is artificially produced in a laboratory rather than derived from tobacco plants

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67 For such a product to be exempt, FDA must determine that (1) the modification would be considered minor, (2) an SE report that demonstrates substantial equivalence would not be necessary to ensure that marketing the tobacco product would be appropriate for protection of public health, and (3) an "exemption is otherwise appropriate." 68 Before the product can be legally marketed, FDA must first grant the product an exemption from demonstrating substantial equivalence

This is not a nicotine replacement, as are the gum and patch

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