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Indeed, considering the clinical overlap not only between the different EDS subtypes but also with other HCTDs [1, 9, 28, 30, 32, 35,36,37,38,39,40,41,42,43,44,45,46,47,48,49], differential diagnosis is not always forthright

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Behavioral changes have also been observed even in the absence of nicotine, as nicotine-free electronic cigarette vapor exposure was shown to result in anxiogenic phenotypes in both male and female mice (81)

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