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However, those early formulas shared the same primary problem as their herbal predecessors: in order to kill the parasites, a horse owner would have to administer a dose that was large enough to be toxic to the horse

Constant exposure to high levels of air pollution and drinking water that has a high level of arsenic can increase your risk of lung cancer

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Retrieved from Berman, J., Dugdale, D

This means that while its not an appropriate method to draw conclusions for general population trends, it gives us detailed insights into patterns of accessing and using substances among people who use them