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DDT) and tributyltin (TBT) activate PPARy receptors and have the effect increasing fat stores not only in the exposed animal but in the offspring of the animals as well.[16,17] Obesogenic chemicals also act as endocrine disruptors that change the set point of the HPA axis which in turn affects energy balance, appetite and the stress response and disruption of this set point early in life could partly account for why many people have such a difficult time losing weight as adults.[38] How Plastics And Environmental Toxins Can Make You Fat: The Human Evidence Research thus far has been limited to animals as it is extraordinarily difficult to conduct such invasive tests in humans, but a growing number in the scientific community is convinced that exposure to chemicals that interfere with hormonal pathways can make the human body susceptible to obesity as well