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The truth is much simpler

Severe peripheral joint laxity is a distinctive clinical feature of spondylodysplastic-ehlersdanlos syndrome (Eds)-b4galt7 and spondylodysplastic-eds-b3galt6

1 However UKs National Health Service states that it is the other toxic chemicals in cigarettes that cause most of the harm from smoking and nicotine itself does not cause cancer, lung disease, heart disease or stroke

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PMID 15217537

In 1967, a review by the Public Health Service of current scientific studies on the subject since the Surgeon Generals report pointed further toward the causal nature of the relationship between smoking, certain diseases, and premature death