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In one study, the total glutathione, reduced glutathione, and protein-bound glutathione content in lung tissue of Sprague-Dawley rats with whole-body exposure to smoke from 2R1 reference cigarettes for 30 days, three times per day, were significantly lower than those in unexposed controls (Park et al

Unexpected findings support concerns The researchers first found that, as expected, mice that were chronically exposed to cigarette smoke had severely damaged lungs and excessive inflammation resembling those in human smokers with emphysema

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