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Moreover, in order to evaluate the wide range of possible toxic effects in vivo studies, groups of animals should be exposed to both the human relevant (low) concentrations of FGRs, as well as the exaggerated or maximum tolerated (high) concentrations, based on solubility and technical feasibility limits

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84 These studies demonstrate that women with clitoral phimosis, introital stenosis, and VGF secondary to LS can be successfully treated with minimally invasive surgical intervention

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