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23521 male and 19201 female participants aged 3549* Number of cigarettes smoked daily Test for trend, p14 59 1014 1519 2024 25+ Males All causes RR 1.56 (1.33 to 1.84) 2.03 (1.85 to 2.22) 2.47 (2.29 to 2.65) 2.78 (2.57 to 3.00) 3.35 (3.09 to 3.64) 3.71 (3.34 to 4.11) ,0.001 RR` 1.57 (1.33 to 1.85) 1.94 (1.77 to 2.12) 2.36 (2.19 to 2.55) 2.66 (2.46 to 2.88) 3.19 (2.93 to 3.46) 3.42 (3.07 to 3.81) ,0.001 Ischaemic heart disease RR 2.65 (2.02 to 3.48) 2.67 (2.24 to 3.17) 3.24 (2.81 to 3.74) 3.89 (3.34 to 4.52) 4.10 (3.49 to 4.82) 4.07 (3.31 to 5.02) ,0.001 RR` 2.74 (2.07 to 3.61) 2.47 (2.06 to 2.94) 3.09 (2.67 to 2.58) 3.70 (3.17 to 4.31) 3.75 (3.18 to 4.42) 3.60 (2.91 to 4.46) ,0.001 All cancer RR 1.09 (0.79 to 1.50) 1.69 (1.44 to 1.98) 2.14 (1.88 to 2.42) 2.45 (2.14 to 2.81) 3.03 (2.63 to 3.49) 3.57 (2.99 to 4.26) ,0.001 RR` 1.08 (0.78 to 1.49) 1.63 (1.38 to 1.92) 2.05 (1.81 to 2.34) 2.37 (2.06 to 2.72) 2.93 (2.54 to 3.38) 3.41 (2.85 to 4.09) ,0.001 Lung cancer RR 2.84 (0.96 to 8.45) 11.94 (6.97 to 20.44) 17.98 (10.92 to 29.61) 20.77 (12.52 to 34.47) 33.48 (20.76 to 55.33) 38.64 (22.74 to 65.65) ,0.001 RR` 2.79 (0.94 to 8.28) 11.30 (6.59 to 19.39) 16.73 (10.14 to 27.60) 19.36 11.65 to 32.18) 31.69 (19.14 to 52.47) 36.22 (21.23 to 61.81) ,0.001 Females All causes RR 1.44 (1.17 to 1.77) 1.90 (1.70 to 2.13) 2.31 (2.08 to 2.57) 3.01 (2.60 to 3.48) 3.29 (2.71 to 4.00) 2.67 (1.63 to 4.38) ,0.001 RR` 1.47 (1.19 to 1.82) 1.90 (1.69 to 2.14) 2.29 (2.01 to 2.56) 2.97 (2.55 to 3.45) 3.14 (2.56 to 3.84) 2.61 (1.59 to 4.28) ,0.001 Ischaemic heart disease RR 2.81 (1.67 to 4.72) 3.69 (2.69 to 5.05) 4.03 (2.97 to 5.48) 5.80 (3.92 to 8.57) 4.51 (2.52 to 8.10) 3.89 (0.96 to 15.81) 0.064 RR` 2.94 (1.75 to 4.95) 3.55 (2.57 to 4.89) 3.78 (2.75 to 5.18) 5.28 (3.50 to 7.97) 4.25 (2.35 to 7.68) 3.53 (0.87 to 14.40) 0.114 All cancer RR 1.11 (0.82 to 1.50) 1.44 (1.22 to 1.69) 1.87 (1.61 to 2.16) 2.18 (1.76 to 2.70) 2.73 (2.08 to 3.57) 2.44 (1.26 to 4.72) ,0.001 RR` 1.14 (0.84 to 1.55) 1.44 (1.22 to 1.71) 1.85 (1.59 to 2.16) 2.22 (1.79 to 2.76) 2.47 (1.86 to 3.29) 2.43 (1.26 to 4.71) ,0.001 Lung cancer RR 5.02 (1.81 to 13.93) 13.06 (7.14 to 23.87) 19.19 (10.76 to 34.21) 30.37 (16.24 to 56.81) 27.68 (13.18 to 58.11) 34.02 (9.77 to 118.44) ,0.001 RR` 5.03 (1.81 to 13.98) 11.85 (6.43 to 21.84) 17.62 (9.80 to 31.66) 28.83 15.28 to 54.38) 23.85 (11.10 to 51.25) 31.95 (9.12 to 111.96) ,0.001 *Participants not reporting cardiovascular disease, diabetes, or treatment for hypertension, nor symptoms of angina pectoris and atherosclerosis obliterans

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