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Once applied to a clean, dry, hairless area of the skin, the patch uses transdermal technology to release nicotine gradually over 24 hours

J Allergy Clin Immunol 136:769780 Hoffmann RF, Zarrintan S, Brandenburg SM, Kol A, de Bruin HG, Jafari S, Dijk F, Kalicharan D, Kelders M, Gosker HR, Ten Hacken NH, van der Want JJ, van Oosterhout AJ, Heijink IH (2013) Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells

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