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Impaired endothelium-dependent relaxation and structural changes in arteries and arterioles lead to stiffening of these vessels and an increase in peripheral vascular resistance and arterial pressure

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Kumar, A., Gulati, R., Singhal, S., Hasan, A., & Khan, A

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It has also been suggested that the strong association between anxiety, depression and smoking could be conceptualised in terms of neuroticism - the general personality trait that encompasses long-term and persistent susceptibility to anxiety and depressive symptoms [62, 63]