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Imbalance of endothelium-derived relaxing and contracting factors

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Evidence for interaction is most apparent in structural and functional lung outcomes: In a comprehensive HRCT/physiology study from New Zealand, emphysema was uncommon among cannabis-only users but more frequent in tobacco-only smokers and highest in dual users, consistent with at least additive-if not synergistic-effects on airway and parenchymal injury (9)