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These changes can be passed on to the next generation, even if the child is not exposed to tobacco smoke

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An extensive review in 2023 provided strong evidence that e-cigarette use could cause short-term lung injury, poisoning, burns, seizures and other symptoms in the lungs, particularly in young people

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Smoking increases oxidative stress and the excess reactive oxygen species (ROS) in cigarette smoke can activate orbital fibroblasts and promote fat expansion and fibrosis, all of which are key features of TED (6)