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most of them were located within 2-kb regions of interrogated CpGs, but some were further apart or even on different chromosomes (Numata et al., 2012)

Additional dysregulation includes phosphorylation of EZH2 (at Ser21) via Akt activation and downregulation of PRC1 component BMI1, further contributes to altered chromatin landscapes and loss of H3K27me3 in E6/E7-expressing cells (Hyland et al., 2011)