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18: 3459 Hodak E, Ben-Shetrit A, Ingber A, et al

By February 2018, just two years after they had become available across the whole of the country, one study found there were 5.23 million HTP users in Japan.[xii] This figure equated to one in four of all Japanese tobacco users and meant 8.3% of men (4.21 million) and 1.9% of women (1.02 million) in the country were HTP consumers

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The final step in the 6-hydroxysphingosine biosynthesis has not been elucidated yet, but it is expected that a similar enzyme is involved in this process