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There was a massive jump in taxation levels in the 2000s, primarily driven by increases in tax rates by the states, and another jump in 2009 due to a $1.01 federal per pack hike

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In addition, urine metabolites of VOCs were creatinine-corrected to obtain covariates adjusted geometric means from the regression models consistent with prior studies using urine biomarkers 9-11

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The pipe-colorers are the Sabbatarians of smoking