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Subgroup findings Only four single-sex-based animal studies 29,49,51,52 were found analyzing oxidative stress in the lung, of which three studies were conducted in male mice 29,49,51 and one study in female mice 52

A publication was excluded if it did not report IQOS-specific data, reported data unrelated to the topic (toxicity and health impact), or if the study was retracted or did not report original data

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doi:10.1016/j.ypmed.2022.107074