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This is a result of carbon monoxide in tobacco smoke binding with hemoglobin to form carboxyhemoglobin in the blood, therefore depleting oxygen supply to the brain and resulting in adverse effects on the brain 7

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Treponemal tests such as TP-PA (Treponema pallidum particle agglutination) or FTA-ABS (Fluorescent Treponemal Antibody Absorption) are considered more specific for confirming syphilis