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Carriers of two 4 alleles (APOE 44 genotype) had the greatest risk of developing dementia after adjusting for potential confounders

Nathanson, Disease prevention as social change: The state, society, and public health in the United States, France, Great Britain, and Canada (Russell Sage Foundation, 2007), pp 109-159 online "Tourists in France could now face fines for smoking on the beach"