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Smoking causes more deaths each year than human immunodeficiency virus (HIV), illegal drug use, alcohol use, motor vehicle injuries, and firearm-related incidents combined (Refs

This is likely to be a reflection of the physical chemistry of individual toxicants (e.g

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Nicotine is an addictive chemical, and evidence suggests that nicotine use during adolescence and young adulthood has long-term impacts on brain development

While not all flavors include diacetyl, many do