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Nevertheless, both intravenous and vapor nicotine self-administration paradigms are valuable tools to investigate various aspects of nicotine dependence, and established protocols demonstrate blood levels of nicotines metabolites, cotinine, 5-hydroxycotinine and cotinine N-oxide, similar to that found in human smokers (60, 62, 65, 7274)

Establishing standardized protocols and pathways to improve and ensure responsiveness and timely callbacks to patients is an effective way to impact patient-practitioner/care team communication and to ensure a safeguard for addressing emergent and urgent patient phone calls

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