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The smoking-attributable mortality cost (SAMC) resulting from dying from disease i among population subgroup j is calculated from: where, SAF is smoking-attributable fraction of death, TDEATH is total number of deaths, PVLE is total discounted present value of lifetime earnings, and mina and maxa are minimum and maximum age groups, respectively

Or this millennium

The harms derived from smoking do not always disappear, although they do reduce over time after quitting (Thomson et al., 2022)

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I dont think most people who smoke are doing so because they want to harm themselves

In studies of duloxetine in smoking and nonsmoking psychiatric patients (not directly related to pain relief), serum levels of the drug were lower in smokers than in nonsmokers, suggesting that tobacco smoke components induce drug-metabolizing enzymes (e.g., cytochrome P450 1A2) [108, 109]